The Christie Charity
Paredes R, Schneider M, Stevens A, et al. EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association. Nucleic Acids Res 2018 – In Press
Hurtado AM, Luengo-Gil G, Chen-Liang TH, et al. Transcriptomic rationale for synthetic lethality targeting ERCC1 and CDKN1A in chronic myelomonocytic leukaemia. Br J Haematol 2018 – Online ahead of print 24 May 2018 [PMID 29797327]
Maiques-Diaz A, Spencer GJ, Lynch JT, et al. Enhancer activation by pharmacologic displacement of LSD1 from GFI1 induces differentiation in acute myeloid leukemia. Cell Rep 2018 Mar 27;22(13):3641-3659 [PMID 29590629]
Maes T, Mascaro C, Tirapu I, et al. ORY-1001, a potent and selective covalent KDM1A inhibitor, for the treatment of acute leukemia. Cancer Cell 2018 Mar 12;33(3):495-511 [PMID 29502954]
Wiseman DH and Somervaille TCP. Nanofluidic allele-specific digital PCR method for quantifying IDH1 and IDH2 mutation burden in acute myeloid leukaemia. Methods Mol Biol 2017;1633:235-55 [PMID 28735491]
Jones S, Ahmet J, Ayton K, et al. Discovery and optimization of allosteric inhibitors of mutant isocitrate dehydrogenase 1 (R132H IDH1) displaying activity in human acute myeloid leukemia cells. J Med Chem 2016 Dec 22;59(24):11120-37 [PMID 28002956]
Wiseman DH, Williams EL, Wilks DP, et al. Frequent reconstitution of IDH2R140Q mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia. Leukemia 2016 Sep;30(9):1946-50 [PMID 27118404]
Somerville TDD, Wiseman DH, Spencer GJ, et al. Frequent derepression of the mesenchymal transcription factor gene FOXC1 in acute myeloid leukemia. Cancer Cell 2015 Sep 14;28(3):329-42. [PMID 26373280]
Wiseman DH, Struys EA, Wilks DP, et al. Direct comparison of quantitative digital PCR and 2-hydroxyglutarate enantiomeric ratio for IDH mutant allele frequency assessment in myeloid malignancy. Leukemia 2015 Dec;29(12):2421-3. [PMID 26088953]
Mould DP, McGonagle AE, Wiseman DH, et al. Reversible inhibitors of LSD1 as therapeutic agents in acute myeloid leukaemia: clinical significance and progress to date. Med Res Rev 2015 May;35(3):586-618. [PMID 25418875]
Korfi K, Mandal A, Furney S, et al. A personalised medicine approach for ponatinib-resitant chronic myeloid leukaemia. Ann Oncol 2015 Jun;26(6):1180-7. [PMID 25712455]
Chakraborty PK, Schmitz-Abe K, Kennedy EK, et al. Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD). Blood 2014 Oct 30;124(18):2867-71. [PMID 25193871]
Wiseman DH, Small HF, Wilks DP, et al. Elevated plasma 2-hydroxyglutarate in acute myeloid leukaemia: association with the IDH1 SNP rs11554137 and severe renal impairment. Br J Haematol 2014 Jul;166(1):145-8. [PMID 24606602]
Wiseman DH, Greystoke BF, Somervaille TCP. The variety of leukemic stem cells in myeloid malignancy. Oncogene 2014 Jun 12;33(24):3091-8. [PMID 23831573].
Lynch JT, Cockerill MJ, Hitchin JR, et al. CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1. Anal Biochem 2013 Nov 1;442(1):104-6. [PMID 23911524].
Wiseman DH, Rajaram J, Wynn RF. In response to: “Hemophagocytosis in acute megakaryocytic leukemia: hemophagocytosis or emperipolesis?” J Pediatr Hematol Oncol 2013 Oct;35(7):578-9. [PMID 24060837].
Wiseman DH, May A, Jolles S, et al. A novel syndrome of congenital sideroblastic anemia, B-cell immunodeficiency, periodic fevers and developmental delay (SIFD). Blood 2013 Jul 4;122(1):112-23 [PMID 23553769].
Wiseman DH, Mercer J, Tylee K, et al. Management of mucoploysaccharidosis type IH (Hurler’s syndrome) presenting in infancy with severe dilated cardiomyopathy: a single institution’s experience. J Inherit Metab Dis 2013 Mar;36(2):263-70. [PMID 22718273]
Wiseman DH, Bonney DK, Wynn RF. Haemophagocytosis by leukaemic megakaryoblasts in acute myeloid leukaemia (megakaryoblastic) with t(1;22)(p13;q13);RBM15-MKL1. J Pediatr Hematol Oncol 2012 Oct;34(7):576-80. [PMID 22469944]
Kausar S, Holloway M, Wiseman D, et al. A strange case of ingrowing toe nails. Am J Hematol 2012 Aug;87(8):819. [PMID 22038772]
Aryal KR, Wiseman D, Siriwardena AK, et al. General surgery in patients with a bleeding diathesis: how we do it. World J Surg 2011 Dec;35(12):2603-10. [PMID: 21953125]
Wiseman DH. Donor Cell Leukaemia: A Review. Biol Blood Marrow Transplant 2011 Jun;17(6):771-89. [PMID 20951819]
Wiseman DH, Das M, Poulton K, et al. Donor cell leukemia following unrelated donor bone marrow transplantation for primary granulocytic sarcoma of the small intestine. Am J Hematol 2011 Mar;86(3):315-8. [PMID 21328426]
Wiseman DH, Hunter HJ, Dennis M. Bullous pyoderma gangrenosum in acute myeloid leukaemia. Eur J Hematol 2007 Jul;79(1):91-2. [PMID 17419746]