Current and previous CPCR work

Current studies

AMMO

A randomised phase 2 study of ASTX727 versus best supportive care in MDS/MPN Overlap Syndromes

CPCR are conducting a sub-study as part of the wider AMMO trial. The patient experience sub-study will use mixed-methods research to gain further understanding of the wider challenges of conducting early phase clinical trials in an older patient cohort, through evaluation of patient experience from screening through to withdrawal from trial/trial end.

The AMMO sub-study involves:

• Measurement of patient experience (PREM-ECM-Prior) at trial entry and during the trial (PREM-ECM-During) at end of cycle 6 and at 12 months
• Longitudinal interviews with patients focusing on trial experience and support needs at trial entry, end of cycle 6 and at 12 months. We will also interview patients who decline to take part or withdraw during trial participation. 

The use and development of Patient Reported Outcome Measures (PROMs) in the Adoptive Cell Therapy (ACT) setting

This work aims to put the patient at the centre of future trials and aid regulatory approval of studies, looking to reduce time and cost during setup. We will contribute to the overall understanding, implementation and evaluation of PROMs for patients receiving ACT. The primary objectives of the study are:

1. To develop an ACT-specific PROM to assess quality of life and symptomatology
2. To determine if the same questions can be applied across the different stages of the ACT treatment and follow-trajectory or if a modular approach may be required
3. To develop guidelines/recommendations for the use of PROMs in ATMP trials 

iPREFER

Patient experiences and preference of treatment for multiple myeloma

iPREFER is a qualitative study focused on gathering data to inform clinical decision making and clinical pathways for people receiving treatment for multiple myeloma. The study objectives are:

• Understand what matters most to people with multiple myeloma when making treatment decisions
• Explore how experiences have differed across different lines of treatment
• Determine if people with multiple myeloma have any preferences for particular treatments 

COMPASS

CPCR are providing data entry support to a quality-of-life sub-study of COMPASS, which is an observational cohort study investigating the role of regular community-based blood sample collection to monitor for disease recurrence in patients after lung cancer surgery. 

Qualitative exploration of Head and Neck cancer Patient Reported Experience of Radiotherapy With focus on Restriction Anxiety and ‘Claustrophobia’

CPCR are providing support to H&N-PRER-RAC, which is a non-interventional study using interviews to explore head and neck cancer patients’ experience of preparing for and completing radiotherapy utilising an immobilisation mask.

This work will generate items for use in a screening tool for validation in later work.

Publications

Research grants 

Christie Patient Centred Research has been successful in securing funding grants for projects from a wide variety of sources such as: 

• Innovate UK
• NIHR - Research for Patient Benefit
• Manchester Academic Health Science Centre (MAHSC)
• NIHR Manchester Biomedical Research Centre
• Lung Cancer Nursing UK
• The Christie Charity
• Greater Manchester Cancer
• Entia
• CellCentric Limited
• GSK Pharmaceuticals
• Roche

As well as funding aligned to the NIHR clinical academic pathway to support Christie clinical staff transition into a career in research.